Pulmonary Delivery of Virosome-Bound Antigen Enhances Antigen-Specific CD4+ T Cell Proliferation Compared to Liposome-Bound or Soluble Antigen

Pulmonary Delivery of Virosome-Bound Antigen Enhances Antigen-Specific CD4+ T Cell Proliferation Compared to Liposome-Bound or Soluble Antigen

Pulmonary administration of biomimetic nanoparticles loaded with antigen may represent an effective strategy to directly modulate adaptive immune responses in the respiratory tract. Depending on the design, virosomes may not only serve as biomimetic antigen carriers but are also endowed with intrinsic immune-stimulatory properties. We designed fluorescently labeled influenza-derived virosomes a...

Soluble extracellular antigen-specific T cell immunoproteins.

Some T cells release proteins that bind specifically to antigens that have not been processed by antigen-presenting cells. These soluble immunoproteins induce or effect antigen-specific T cell functions in immunoregulation and/or hypersensitivity. After certain immunization regimens, T cell immunoproteins specific for the immunogen rise in serum, and therefore may be an antigen-specific, humora...

Antigen-Specific CD4 T Cells

Antigen-specific T-T interactions regulate CD4 T-cell expansion.

The regulation of CD4 T-cell numbers during an immune response should take account of the amount of antigen (Ag), the initial frequency of Ag-specific T cells, the mix of naive versus experienced cells, and (ideally) the diversity of the repertoire. Here we describe a novel mechanism of T-cell regulation that potentially deals with all of these parameters. We found that CD4 T cells establish a ...

The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T[emsp13]cells

1 Children's Hospital, University of Tuebingen, Tuebingen, Germany 2 Benaroya Research Institute, Virginia Mason Research Center, Seattle, USA 3 Department of Transfusion Medicine, University of Tuebingen, Tuebingen, Germany 4 Medical and Natural Sciences Research Centre (MNF), University of Tuebingen, T bingen, Germany 5 Department of Pediatrics and Pediatric Rheumatology, Olgahospital, Stuttg...